A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1
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چکیده
منابع مشابه
Inhibitory Effect of b-AP15 on the 20S Proteasome
The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome ...
متن کاملThe immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes.
Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but accumulate with age and disease. We demonstrate the importance of various forms of the proteasome during transient (reversible) adaptation (hormesis), to oxidative stress in murine embryonic fibroblasts. Adaptation was achieved by 'pre-treatment' with very low concentrations of H2O2, and tested by measuring i...
متن کاملThe subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome.
Processing of antigens for presentation by major histocompatibility complex (MHC) class I molecules requires the activity of the proteasome. The 20S proteasome complex is composed of 14 different subunits, 2 of which can be substituted by the interferon gamma (IFN-gamma)-inducible and MHC-encoded subunits LMP2 and LMP7 (low molecular mass poylpeptides 2 and 7). A third subunit, MECL-1, is induc...
متن کاملThe proteasome regulator PA28 > / I can enhance antigen presentation without affecting 20S proteasome subunit composition
PA28 § / g is a regulatory complex of the 20S proteasome which consists of two IFN+ inducible subunits. Both subunits, § and g , contribute equally to the formation of hexaor heptameric rings which can associate with the 20S proteasome. Previously, we have shown that overexpression of the PA28 § subunit enhanced the MHC class I-restricted presentation of two viral epitopes and that purified PA2...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2012
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2012.05.049